Design, synthesis, and in vitro pharmacology of new radiolabeled ¿-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity ¿-hydroxybutyric acid binding sites
Research output: Contribution to journal › Journal article › Research › peer-review
gamma-Hydroxybutyric acid (GHB) is a psychotropic compound endogenous to the brain. Despite its potential physiological significance, the complete molecular mechanisms of action remain unexplained. To facilitate the isolation and identification of the high-affinity GHB binding site, we herein report the design and synthesis of the first (125)I-labeled radioligands in the field, one of which contains a photoaffinity label which enables it to bind irreversibly to the high-affinity GHB binding sites.
Original language | English |
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Journal | Journal of Medicinal Chemistry |
Volume | 53 |
Issue number | 17 |
Pages (from-to) | 6506-6510 |
ISSN | 0022-2623 |
DOIs | |
Publication status | Published - 2010 |
- Former Faculty of Pharmaceutical Sciences
Research areas
ID: 21772547